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[60] reported decreases in MT mRNA levels in response to high glucose concentration in -cells in a mice model

strongly suggest that vesicular release from astrocytes plays a minor role, as the Ca +2 -mediated release of L-glu was still present in astrocytes derived from dominant-negative SNARE mice (Wang et al., 2013) where vesicular release can be blocked by doxycycline withdrawal (Pascual et al., 2005)

EXOs have been linked to macrophage polarization, and exo-miRNAs have been shown to be putative modulators of cancer development

Interestingly, the inflammation score remained unchanged in this transcriptomic analysis regardless of L-serine treatment (Supplementary Fig